Association of ADAM33 polymorphisms to the presence, severity and control of asthma in a Brazilian sample population
نویسندگان
چکیده
منابع مشابه
Association of ADAM33 gene polymorphisms with allergic asthma
Objective(s): Asthma results from the interaction between genetic and environmental factors. ADAM33 gene on chromosome 20p13 is associated with asthma and airway hyperresponsiveness. Materials and Methods: This is a case-control study, where four SNPs S1 (rs3918396), T1 (rs2280091), T2 (rs2280090), V4 (rs2787094) of ADAM33 gene have been assessed in patients with allergic asthma and normal con...
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BACKGROUND ADAM 33 is the first gene identified as a candidate for asthma by positional cloning techniques, with association studies reaching impressive statistical significance. It has a postulated role in myogenesis, airway modelling, and signalling via protein shedding. Concerns over the methodology of the initial study have led to several attempts at replication, with inconsistent results. ...
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ژورنال
عنوان ژورنال: Revista dos Trabalhos de Iniciação Científica da UNICAMP
سال: 2018
ISSN: 2596-1969
DOI: 10.20396/revpibic262018168